https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25807 Wed 09 Feb 2022 15:57:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31414 6-methylguanine adduct. This activates the mismatch repair (MMR) process inducing apoptosis and mutagenesis. This review describes key juxtaposed drivers in the balance between alkylation induced mutagenesis and apoptosis. Mutations in MMR genes are the probable drivers for alkylation based drug resistance. Critical to this interaction are the dose-response and temporal interactions between adduct formation and MMR mutations. The precision in dose interval, dose-responses and temporal relationships dictate a role for alkylating agents in either promoting experimental tumour formation or inducing tumour cell death with chemotherapy. Importantly, this resultant loss of chemotherapeutic selective pressure provides opportunity to explore novel therapeutics and appropriate combinations to minimise alkylation based drug resistance and tumour relapse.]]> Thu 17 Feb 2022 09:26:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24507 0.90). After adjusting for age, admission status, and treatment, excellent HRQoL was more likely among participants of Torres Strait Islander origin [adjusted odds ratio (AOR) 3.68; 95 % CI 1.23–11.01], those living in regional areas (AOR 5.59; 95 % CI 1.42–22.06), and those whose main language spoken at home was not English (AOR 3.60; 95 % CI 1.08–11.99) and less likely among those reporting less contact with Indigenous people (AOR 0.23; 95 % CI 0.68–0.81). Conclusion: Assessing HRQoL is important to identifying and improving the length and quality of cancer survivorship, especially in groups that have significantly poorer cancer outcomes, such as Indigenous Australians. Acknowledging the study’s observational nature, we found HRQoL was lower than reported for other Australians, and we identified some socio-demographic factors that were associated with excellent HRQoL. Such assessments are an important component of identifying and evaluating appropriate interventions to improve the health and well-being of Indigenous cancer patients.]]> Thu 13 Jan 2022 10:30:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24648 Thu 13 Jan 2022 10:28:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24803 Thu 09 Dec 2021 11:02:03 AEDT ]]>